Welcome to my research page! I’m glad we share an excitement for the raw data.
For ease in answering questions, I’ve linked each statement to the medline research abstract. Just click on the statement to have the study open up in a new window for your reading pleasure. The web is constantly changing, so let me know if any of these links are no longer working.
Chapter 2: Finding the Colon Cancer Diet.
- Laparoscopic surgery is better for colon cancer.
- But perhaps because open surgery happens in worse cases.
Chapter 3: Does It Run In Your Family?
- Having a relative increases the risk of adenomas (polyps) and we’re not sure about cancer.
- Having a relative with colon cancer doubles your risk, and younger relatives are worse.
- Only about five percent of colon cancers are the direct result of genetic inheritance though about a third of colon cancer patients have a family history.
- Lynch Syndrome families may get unnecessary testing.
- Full article on Lynch Syndrome and the search for other genetically inherited colon cancers.
- Treatment options and early surgery in familial polyposis patients.
- Continence issues for familial polyposis patients.
- Psychological effects of having early familial polyposis.
- New Zealand and Israeli estimates of the rates of familial polyposis.
Chapter 4: What Causes 95% Of Colon Cancer?
- Complete article on colon cancer and the five percent due to genetics.
- The effect of diet is so important that 90% of gastrointestinal cancers are due to differences in diet.
Chapter 5: What To Avoid
- A standard American diet causes cancer in the colons of mice.
- Mouse studies don’t equal human studies.
- Diet contributes 35% to the onset of (all) cancer.
- People with colon cancer who ate the most red meat and sugary snacks had three times the rate of cancer recurrence as those who ate the least meat and sugar.
- Avoiding red meat reduces the risk of cancers of the colon and rectum.
- The risk of cancer is related to the frequency of red meat consumption.
Chapter 6: What To Eat
- One medical reviewer says all colon cancer patients should adapt the Mediterranean diet.
- Healthy volunteers show no change in colon cancer predicting gut markers on either the Healthy Eating or Mediterranean diet.
- In a test tube, extra virgin olive oil did slow down colon cancer cells.
- The “olive oil and salad” model does lead to lower death overall in the elderly.
- The Cochrane analysis in 2002 found no difference in colon cancer rates based on fiber intake.
- Other experts say eating foods high in dietary fiber shows convincing prevention of colon cancer.
- In smaller, more recent studies fiber did help, but only for lower colon cancer, and not necessarily for recurring cancers.
- If you have a right sided (upper) or transverse (middle) colon cancer, it turns out that 89% of you may have biofilms next to your tumor. The biofilms are not only where your tumor was but also scattered over the rest of your upper colon. It was a pretty small study that found the biofilms, so you could ignore it. But the study was done by John Hopkins on patients in the U.S. and in Malaysia. Both sets of patients with upper colon cancers had the same biofilms.
Chapter 7: What To Eat On Chemo And Radiation
- Colon cancer chemo patients who ate more calories died at the same rate.
- A lacto-vegetarian diet with abundant amounts of vegetables and fruits reduces the risk of developing colorectal cancer.
- Vegetarian diets lower the incidence of colorectal cancers. Pescovegetarians have a much lower risk compared with nonvegetarians.
- A trial of fish oil added to the diets of cachexic patients allowed for longer rounds of chemo.
- IV fish oil wasn’t a good idea (more complications.)
- We have no data on diet and nausea during chemo for colon cancer patients.
- Many foods and spices may help with colon cancer but combinations (e.g. consumed in the diet) have never been studied.
- More antioxidants didn’t help more than avoiding meat. with the possible exception of turmeric.
- High dose onion extract was equivalent to capecitabine.
- At 20% of the diet, onions made colon cancer grow in rats. But a 5% onion diet blocked colon cancer.
- In a small study of advanced cancer patients, taking just turmeric may have benefited some but the turmeric wasn’t absorbed into the body to help with metastases.
- Glutamine blocks stress, helps build weight, and helps the immune system.
- Whey-hydrolyzed peptide, fermented milk, and isomaltulose may be helpful in combination with chemotherapy to prevent cancer cachexia without interfering with the chemotherapy.
- Two apples a day to keep colon cancer at bay.
Chapter 8: Extreme Diets
- Dr. Gerson said his dietary regime, followed to the letter (including liver juice and coffee enemas) could cure advanced cancer.
- But the Gerson Diet pancreatic cancer patients died far faster, less than 20% surviving a year compared to over half the chemotherapy group.
- One small study done gives a possible benefit for stage IV colon cancer, but the study was on eighteen patients and didn’t follow Gerson’s diet guidelines.
- As the Gerson Institute says, “The Gerson Therapy has its limitations, and we can make no guarantees about its effectiveness for every individual; recovery is on a case-by-case basis.”
- “Prudent” patients had the same survival rate as the middle group that just avoided lots of red meat and sugar.
Chapter 9: Supplements
- The effects of thyme were dose and time dependent so maybe more is better, but we all realize that there is only so much thyme you can take before your stomach rebels.
- It was so successful that all Lynch Syndrome patients are recommended to take it.
- This supplement decreased our risk of getting polyps after one to three years.
- It cut in half the estimated rate of death (mortality) among colon cancer patients who started taking it after their diagnosis. That’s right, one supplement halved the rate of death of people like you and me.
- The highest levels of vitamin D in your blood really lowers your mortality rates, by almost half. But that study could be more about the overall lifestyle of people who take vitamin D rather than the vitamin D alone.
- Calcium showed less polyp growth, but had no effect in advanced colon cancer.
- Several compounds in coffee block colon cancer growth.
- The protective effect of coffee shows up at about four cups a day!
- Coffee: while it lowered colon cancer it increased rectal cancer by almost as much!
Chapter 10: Does Exercise Help With Colon Cancer?
- Being overweight raises colon cancer risk by almost 20%. Regular physical activity reduces this risk by 24%.”
- Low physical activity levels cause 10% of colon cancer cases.
- In the U.S. risks for colon cancer were higher for highest TV viewing time.
- In three hundred studies on all cancers and exercise, researchers found the evidence of physical activity and cancer risk to be strong for colon cancer.
- Consistent evidence from 27 observational studies on physical activity show reduced colon cancer-specific mortality.
- Women who were most physically active experienced 61% reduced colorectal cancer–specific mortality.
- Men who did one hour of walking per day had a less than half the risk of dying.
- Patients are still at risk for other common malignancies (lung, breast, cervix, prostate).
Chapter 11: Anaerobic Vs. Aerobic Exercise.
- Studies have suggested that aerobic glycolysis is high in malignant tumors. Probably, it correlates with high glucose intake of cancerous tissues. This observation is contrary to Warburg’s theory that the main way of energy generation in cancer cells is non-oxidative glycolysis. Further studies have suggested that in tumor cells both oxidative phosphorylation and glycolysis were active at various rates. An increase of intracellular oxidative stress induces damage of cellular structure and somatic mutations. Further studies confirmed that permanent activity of oxidative stress and the influence of chronic inflammation damage the healthy neighboring epithelium and may lead to carcinogenesis.”
- No significant differences between groups. Measures of the enjoyment of the training program indicated that the Tabata protocol was significantly less enjoyable (p < 0.05) than the steady state and Meyer protocols, and that the enjoyment of all protocols declined (p < 0.05) across the duration of the study”
- Several psychosocial interventions, particularly those based on cognitive-behavioural therapy, have been demonstrated to represent good value for money in cancer care”
- cfDNA increased (15-fold) 30-min post-exercise and normalized thereafter. hs-CRP increased (56%, p<0.001) 1h post-exercise, remained elevated throughout recovery (52-142%, p<0.0001), and peaked (200% rise, p<0.0001) at 24h post-exercise. UA and CK increased (p<0.05), immediately post-exercise, remained elevated throughout recovery (p<0.0001), and peaked (p<0.0001) at 24h of post-exercise recovery.”
- “data indicate that intravascular NETs (neutrophil extracellular traps) are released during intensive exercise. NETs were originally described as an innate defense mechanism to extracellularly capture and potentially kill invading pathogens… It is noteworthy that strenuous or exhaustive exercise is known to elicit a transient hypercoagulable state characterized by platelet activation as well as selective stimulation of secondary hemostasis via the intrinsic coagulation pathway.”
- “our results suggest that prolonged moderate treadmill exercise can transiently reduce plasma cf‐mDNA levels, while inducing a rise in plasma IL‐6.
- “difference in cf-mDNA response was observed between exercise and control trials, with cf-mDNA levels reduced during exercise at +54 and +90 (with or without plasma volume shift correction).”
Chapter 12: A Call For More Research.
Remission is great, but what about survival rates? Of those patients Huber tracked, 36% of those who ate sugar survived. But in the patients who avoided sugar, the survival rate was 83%. Yes, that’s enough to make me want to avoid all sugar for a long time to come.
Unfortunately, some cancer cells can make the cells around them their “zombie slaves” and those cells produce the compounds they need even if sugar isn’t available. That paradox is the “reverse Warburg effect“. These cells surrounding the cancer will protect it from any efforts to kill it off by depriving it of sugar.